Yes! There are a few different ways to integrate with XPS Ship.
XPS Ship offers prebuilt integrations for most major eCommerce platforms. Visit the following article for a listing of prebuilt solutions: What shopping carts are supported through XPS Ship?
If you utilize a system that is not one of the prebuilt integration you can use the Custom Integration options; For more details visit the link: What is the REST/Webhooks APIs in the cart integrations used for?
You can also use the CSV integration option to generate orders from a shopping cart not yet supported or from a custom website. For more details visit the Help Center article: CSV Importing